Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes

@article{Serrano2012LysineDT,
  title={Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes},
  author={Guilherme Coutinho de Mello Serrano and Tha{\'i}s Rezende e Silva Figueira and E. Kiyota and Natalia Zanata and P. Arruda},
  journal={FEBS Letters},
  year={2012},
  volume={586}
}
Lysine degradation through the saccharopine pathway has been shown only in plants and animals. Here, we show that bacteria possess the genes encoding lysine‐ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH). In Silicibacter, the contiguous lkr and sdh genes are interspersed, in another frame, by a polypeptide of unknown function. The bacterial enzyme does not contain the 110‐amino‐acid interdomain (ID) that intersperses the LKR and SDH domains of the plant enzyme. The ID was… Expand
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