Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes

@article{deMelloSerrano2012LysineDT,
  title={Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes},
  author={Guilherme Coutinho de Mello Serrano and Tha{\'i}s Rezende e Silva Figueira and Eduardo Kiyota and Natalia Zanata and Paulo Arruda},
  journal={FEBS Letters},
  year={2012},
  volume={586}
}
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References

SHOWING 1-10 OF 24 REFERENCES
α-Aminoadipate Pathway for the Biosynthesis of Lysine in Lower Eukaryotes
TLDR
The lysine pathway of S. cerevisiae is regulated by feedback inhibition and end product repression and at least five of the enzymes coded for, by unlinked genes, are simultaneously depressed in a regulatory (repressor) gene-mutant.
alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes.
TLDR
The lysine pathway of S. cerevisiae is regulated by feedback inhibition and end product repression and at least five of the enzymes coded for, by unlinked genes, are simultaneously depressed in a regulatory (repressor) gene-mutant.
Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence
TLDR
The first isolation and biochemical characterization of a prokaryotic sucrose synthase is described, showing some striking differences from plant enzymes with respect to substrate affinities, regulation by metal ions and ATP, and the amino-acid sequence of the N-terminal region.
The Role of Opaque2 in the Control of Lysine-Degrading Activities in Developing Maize Endosperm
TLDR
The results suggest that lysine levels in the endosperm are likely to be controlled at the transcriptional level by the Opaque2 transcription factor.
Structure and regulation of the bifunctional enzyme lysine-oxoglutarate reductase-saccharopine dehydrogenase in maize.
TLDR
The results suggest that the LOR activity of the native enzyme is normally inhibited such that after modulation, the enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding.
Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize
TLDR
Limited proteolysis with elastase indicated that lysine-ketoglutarate reductase and saccharopine dehydrogenase from maize endosperm are located in two functionally independent domains of a bifunctional polypeptide.
Analysis of the aspartic acid metabolic pathway using mutant genes
TLDR
An overview of the aspartic acid metabolic pathway, the key regulatory enzymes and the mutants and transgenic plants produced for lysine and threonine metabolism is presented.
The aspartic acid metabolic pathway, an exciting and essential pathway in plants
Summary.Aspartate is the common precursor of the essential amino acids lysine, threonine, methionine and isoleucine in higher plants. In addition, aspartate may also be converted to asparagine, in a
Regulation of lysine catabolism in higher plants.
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