Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

@article{Lundh2010LysineDA,
  title={Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines},
  author={Morten Lundh and Dan Ploug Christensen and Daniel Rasmussen and Paolo Mascagni and Charles A Dinarello and Nils Billestrup and Lars Groth Grunnet and Thomas Mandrup-Poulsen},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={2569-2578}
}
Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non… CONTINUE READING

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The KDAC family consists of 11 members , namely histone deacetylases HDAC1 to HDAC11 , but it is not known which KDAC members play a role in cytokine - mediated beta cell death .
The KDAC family consists of 11 members , namely histone deacetylases HDAC1 to HDAC11 , but it is not known which KDAC members play a role in cytokine - mediated beta cell death .
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