Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

Abstract

Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile… (More)
DOI: 10.1007/s00125-010-1892-8

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