Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

@inproceedings{Valor2013LysineAC,
  title={Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders},
  author={Luis M Valor and Jos{\'e} Viosca and Jos{\'e} P. L{\'o}pez-Atalaya and Angel Barco},
  booktitle={Current pharmaceutical design},
  year={2013}
}
Neuropsychiatric pathologies, including neurodegenerative diseases and neurodevelopmental syndromes, are frequently associated with dysregulation of various essential cellular mechanisms, such as transcription, mitochondrial respiration and protein degradation. In these complex scenarios, it is difficult to pinpoint the specific molecular dysfunction that initiated the pathology or that led to the fatal cascade of events that ends with the death of the neuron. Among the possible original… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 211 references

Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation, but does not affect cell viability

  • LM Valor, MM Pulopulos, M Jimenez-Minchan, R Olivares, B Lutz, A. Barco
  • J. Neurosci
  • 2011
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…