Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
@article{Choudhary2009LysineAT,
title={Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions},
author={C. Choudhary and Chanchal Kumar and Florian Gnad and M. L. Nielsen and Michael Rehman and T. Walther and J. V. Olsen and M. Mann},
journal={Science},
year={2009},
volume={325},
pages={834 - 840}
}Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the activity of proteins can be controlled. Advances in mass spectrometry made it possible for Choudhary et al. (p. 834, published online 16 July) to assess the prevalence of lysine acetylation throughout the whole proteome. Acetylation is much more widespread than previously appreciated and occurs on proteins participating in all sorts of biological functions. Acetylation… CONTINUE READING
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