Lysibodies are IgG Fc fusions with lysin binding domains targeting Staphylococcus aureus wall carbohydrates for effective phagocytosis

@article{Raz2017LysibodiesAI,
  title={Lysibodies are IgG Fc fusions with lysin binding domains targeting Staphylococcus aureus wall carbohydrates for effective phagocytosis},
  author={Assaf Raz and Anna Claudia Marques Serrano and Christine Lawson and Maneesha Thaker and Tricia Alston and Stylianos Bournazos and Jeffrey V. Ravetch and Vincent A. Fischetti},
  journal={Proceedings of the National Academy of Sciences},
  year={2017},
  volume={114},
  pages={4781 - 4786}
}
Significance Antibiotic resistance is an ever-increasing problem; for certain pathogens, few treatment options remain. Vaccines and therapeutic antibodies represent important alternatives to antibiotics, yet despite extensive effort no approved vaccine is available for Staphylococcus aureus. Although wall carbohydrates are ideal immunotherapeutic targets due to their abundance and high level of conservation, their poor immunogenicity compared with conventional protein targets complicates the… 

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