Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

  title={Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials},
  author={Teri Suzanne Krebs and P{\aa}l-{\O}rjan Johansen},
  journal={Journal of Psychopharmacology},
  pages={1002 - 994}
Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was… 

Figures and Tables from this paper

Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials

The evidence to date is strongest for the use of LSD in the treatment of alcoholism, and new studies that conform to modern standards are necessary in order to strengthen knowledge on its use and open new doors in the future.

A review of lysergic acid diethylamide (LSD) in the treatment of addictions: historical perspectives and future prospects.

It is concluded that further research into LSD's potential as a treatment for addictions is warranted.

Cessation and reduction in alcohol consumption and misuse after psychedelic use

It is suggested that naturalistic psychedelic use may lead to cessation or reduction in problematic alcohol use, supporting further investigation of psychedelic-assisted treatment for AUD.

A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy

Overall, analyses support the efficacy of psychedelic-assisted therapy across four mental health conditions – post-traumatic stress disorder, anxiety/depression associated with a life-threatening illness, unipolar depression, and social anxiety among autistic adults.

Post-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis

The effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period are quantified and test moderators of these effects are evaluated; adverse effects and risk of bias are evaluated.

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Treating drug dependence with the aid of ibogaine: A retrospective study

A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs.

Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years

A systematic review of clinical trials published from 1990 until 2015 concluded that ayahuasca, psilocybin and LSD may be useful pharmacological tools for the treatment of drug dependence, and anxiety and mood disorders, especially in treatment-resistant patients.

Acute subjective effects in LSD- and MDMA-assisted psychotherapy

LSD and MDMA are currently used medically in Switzerland mainly in patients with posttraumatic stress disorder and depression in group settings, producing similar acute responses as in research subjects.

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants

The 20 µg dose of LSD significantly increased ratings of “under the influence,’ “good drug effects,” and “bad drug effects” compared with placebo and LSD concentrations dose‐proportionally increased at doses as low as 5–20 µg and decreased with a half‐life of 3 hours.




It is indicated that the long term gains through use of LSD are negligible and a successful post-treatment adjustment seems more closely associated with pretreatment employment level, marital status, and whether or not the patient completes the treatment program.

Lysergic Acid Diethylamide (LSD) in the Treatment of Alcoholism: An Investigation of Its Effects on Drinking Behavior, Personality Structure, and Social Functioning

This latest volume on LSD therapy gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds it wanting.

Acamprosate for alcohol dependence?

Acamprosate appears to be an effective and safe treatment strategy for supporting continuous abstinence after detoxification in alcohol dependent patients and should be valued against the background of the relapsing nature of alcoholism and the limited therapeutic options currently available for its treatment.

A controlled study of lysergide in the treatment of alcoholism. 1. The effects on drinking behavior.

These trials are characterized by a lack of the very control groups, follow-up procedures, and measures of change which would allow any valid statement about lysergide to be made.

The Pharmacology of Lysergic Acid Diethylamide: A Review

There is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.

Opioid antagonists for alcohol dependence.

Findings support that short-term treatment of NTX decreases the chance of alcohol relapses for 36% (number-needed-to-treat or NNT = 7) and likely to reduce the chances of returning to drinking for 13% (NNT = 12), and NTX treatment can lower the risk of treatment withdrawal in alcohol-dependent patients for 28% (NTT = 13).

A Controlled Study of LSD Treatment in Alcoholism and Neurosis

In this experiment, alcoholics and neurotics who had been referred by Saskatoon psychiatrists for LSD treatment were allocated at random to Treatment and Control groups after undergoing a series of psychological tests.

Treatment of alcoholism using psychedelic drugs: a review of the program of research.

  • M. Mangini
  • Psychology
    Journal of psychoactive drugs
  • 1998
The history of one branch of psychedelic research, the therapeutic use of LSD in the treatment of alcoholism, and of the events that led to the relabeling of the "hallucinogens" as drugs of abuse are explored.

Treatment of Chronic Alcoholism with Lysergic Acid Diethylamide *

Some aspects of the LSD-25 treatment given to alcoholics in Weyburn, Saskatchewan are described and it is considered that they are quite encouraging.

A clinical study of LSD treatment in alcoholism.

It is concluded that the dramatic claims for the efficacy of LSD treatment in alcoholism are unjustified and no one treatment condition proved to be superior.