Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

@article{Krebs2012LysergicAD,
  title={Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials},
  author={Teri Suzanne Krebs and P{\aa}l-{\O}rjan Johansen},
  journal={Journal of Psychopharmacology},
  year={2012},
  volume={26},
  pages={1002 - 994}
}
Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was… 
View on SAGE
ntnu.edu
299 Citations
Highly Influential Citations
9
Background Citations
89
Methods Citations
28
Results Citations
15

299 Citations

Citation Type

Citation Type

Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials
TLDR
The evidence to date is strongest for the use of LSD in the treatment of alcoholism, and new studies that conform to modern standards are necessary in order to strengthen knowledge on its use and open new doors in the future.
A review of lysergic acid diethylamide (LSD) in the treatment of addictions: historical perspectives and future prospects.
TLDR
It is concluded that further research into LSD's potential as a treatment for addictions is warranted.
A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy
TLDR
Overall, analyses support the efficacy of psychedelic-assisted therapy across four mental health conditions – post-traumatic stress disorder, anxiety/depression associated with a life-threatening illness, unipolar depression, and social anxiety among autistic adults.
Cessation and reduction in alcohol consumption and misuse after psychedelic use
TLDR
It is suggested that naturalistic psychedelic use may lead to cessation or reduction in problematic alcohol use, supporting further investigation of psychedelic-assisted treatment for AUD.
Post-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis
TLDR
The effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period are quantified and test moderators of these effects are evaluated; adverse effects and risk of bias are evaluated.
Lysergic acid diethylamide: a drug of ‘use’?
TLDR
The receptor pharmacology, mechanism of action, effects and adverse effects of LSD on the normal body system are described, and its addictive potentials and the chances of developing tolerance are highlighted.
Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects
TLDR
In addition to marked hallucinogenic effects, LSD exerts methylenedioxymethamphetamine-like empathogenic mood effects that may be useful in psychotherapy, supporting the use of LSD in translational psychiatric research.
Treating drug dependence with the aid of ibogaine: A retrospective study
TLDR
A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs.
Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years
TLDR
A systematic review of clinical trials published from 1990 until 2015 concluded that ayahuasca, psilocybin and LSD may be useful pharmacological tools for the treatment of drug dependence, and anxiety and mood disorders, especially in treatment-resistant patients.
Acute subjective effects in LSD- and MDMA-assisted psychotherapy
TLDR
LSD and MDMA are currently used medically in Switzerland mainly in patients with posttraumatic stress disorder and depression in group settings, producing similar acute responses as in research subjects.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
LYSERGIC ACID DIETHYLAMIDE AS A VARIABLE IN THE HOSPITAL TREATMENT OF ALCOHOLISM: A FOLLOW‐UP STUDY
TLDR
It is indicated that the long term gains through use of LSD are negligible and a successful post-treatment adjustment seems more closely associated with pretreatment employment level, marital status, and whether or not the patient completes the treatment program.
Lysergic Acid Diethylamide (LSD) in the Treatment of Alcoholism: An Investigation of Its Effects on Drinking Behavior, Personality Structure, and Social Functioning
TLDR
This latest volume on LSD therapy gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds it wanting.
Acamprosate for alcohol dependence?
TLDR
Acamprosate appears to be an effective and safe treatment strategy for supporting continuous abstinence after detoxification in alcohol dependent patients and should be valued against the background of the relapsing nature of alcoholism and the limited therapeutic options currently available for its treatment.
A controlled study of lysergide in the treatment of alcoholism. 1. The effects on drinking behavior.
TLDR
These trials are characterized by a lack of the very control groups, follow-up procedures, and measures of change which would allow any valid statement about lysergide to be made.
The Pharmacology of Lysergic Acid Diethylamide: A Review
TLDR
There is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.
Opioid antagonists for alcohol dependence.
TLDR
Findings support that short-term treatment of NTX decreases the chance of alcohol relapses for 36% (number-needed-to-treat or NNT = 7) and likely to reduce the chances of returning to drinking for 13% (NNT = 12), and NTX treatment can lower the risk of treatment withdrawal in alcohol-dependent patients for 28% (NTT = 13).
Treatment of alcoholism using psychedelic drugs: a review of the program of research.
  • M. Mangini
  • Psychology, Medicine
    Journal of psychoactive drugs
  • 1998
TLDR
The history of one branch of psychedelic research, the therapeutic use of LSD in the treatment of alcoholism, and of the events that led to the relabeling of the "hallucinogens" as drugs of abuse are explored.
Treatment of Chronic Alcoholism with Lysergic Acid Diethylamide *
TLDR
Some aspects of the LSD-25 treatment given to alcoholics in Weyburn, Saskatchewan are described and it is considered that they are quite encouraging.
A clinical study of LSD treatment in alcoholism.
TLDR
It is concluded that the dramatic claims for the efficacy of LSD treatment in alcoholism are unjustified and no one treatment condition proved to be superior.
A controlled study of LSD treatment in alcoholism and neurosis.
  • R. Denson, D. Sydiaha
  • Medicine
    The British journal of psychiatry : the journal of mental science
  • 1970
TLDR
Members of the Treatment psychiatrists for LSD treatment were allocated group received a total of 79 LSD experiences, and standard treatment to the members of the Control group were started with larger doses if the drug both groups.
...
1
2
3
4
...