Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.

Abstract

A major factor contributing to the high mutation rate of HIV-1 reverse transcriptase (RT) is its high propensity for misincorporation. Misincorporation requires both deoxyribonucleotide triphosphate (dNTP) misinsertion and the subsequent extension of the mismatched terminus thus formed. We hypothesized that Lys66 is a determinant of mismatch extension based… (More)
DOI: 10.1111/j.1742-4658.2012.08807.x

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Cite this paper

@article{Lwatula2012Lys66RA, title={Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.}, author={Chisanga Lwatula and Scott J. Garforth and V. Rajendra Prasad}, journal={The FEBS journal}, year={2012}, volume={279 21}, pages={4010-24} }