Lys05: a new lysosomal autophagy inhibitor.

  title={Lys05: a new lysosomal autophagy inhibitor.},
  author={Ravi K Amaravadi and Jeffrey D Winkler},
  volume={8 9},
Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Initial structure-activity relationship studies demonstrated that the increased activity associated with Lys05 was due to the bivalent aminoquinoline rings, C7-Chlorine, and a short triamine… CONTINUE READING


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