Lys-17 is the amine-donor substrate site for transglutaminase in beta A3-crystallin.

@article{Groenen1994Lys17IT,
  title={Lys-17 is the amine-donor substrate site for transglutaminase in beta A3-crystallin.},
  author={Patricia J. T. A. Groenen and Joep Grootjans and N. H. Lubsen and Hans Bloemendal and Wilfried W. de Jong},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 2},
  pages={831-3}
}
The bovine lens protein beta A3-crystallin has recently been shown to be an amine-donor (Lys) substrate for tissue-type transglutaminase, using a newly developed amine-acceptor hexapeptide as a probe (Groenen, P.J.T.A., Seccia, M., Smulders, R.H.P.H., Gravela, E., Cheeseman, K.H., Bloemendal, H., and de Jong, W.W. (1993) Biochem. J. 295, 399-404). In the present study, the reactive amine-donor site has been identified by site-directed mutagenesis of the putative substrate lysine. The mutation… CONTINUE READING

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