Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.

@article{Morishita2010Lynx1AC,
  title={Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.},
  author={Hirofumi Morishita and Julie M Miwa and Nathaniel Heintz and Takao K Hensch},
  journal={Science},
  year={2010},
  volume={330 6008},
  pages={1238-40}
}
Experience-dependent brain plasticity typically declines after an early critical period during which circuits are established. Loss of plasticity with closure of the critical period limits improvement of function in adulthood, but the mechanisms that change the brain's plasticity remain poorly understood. Here, we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic… CONTINUE READING
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