Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer.

@article{Mills2014LynchSS,
  title={Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer.},
  author={Anne M Mills and Sofia Ya-Hsuan Liou and James M. Ford and Jonathan S. Berek and Reetesh K Pai and Teri A. Longacre},
  journal={The American journal of surgical pathology},
  year={2014},
  volume={38 11},
  pages={1501-9}
}
Lynch syndrome (LS) is an autosomal dominant inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Mutation carriers are at substantially increased risk of developing cancers of the colorectum and endometrium, among others. Given recent recommendations for universal, cost-effective screening of all patients with newly diagnosed colorectal cancer using MMR protein immunohistochemistry, we evaluated MMR protein expression in a series of endometrial cancers in the… CONTINUE READING
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