Lynch syndrome and related familial colorectal cancers.

  title={Lynch syndrome and related familial colorectal cancers.},
  author={Wael M Abdel-Rahman and P{\"a}ivi Peltom{\"a}ki},
  journal={Critical reviews in oncogenesis},
  volume={14 1},
  pages={1-22; discussion 23-31}
Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC) refers to autosomal dominant predisposition to colorectal, endometrial, and a spectrum of other cancers. The syndrome is due to heterozygous germ line mutations in one of the mismatch repair genes MLH1, MSH2, MSH6, and PMS2. Amsterdam I and II criteria for clinical diagnosis and Bethesda guidelines for molecular testing of suspected patients usually point out additional families in which there is no evidence of mismatch repair… CONTINUE READING