Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.

@article{Chin1998LynPA,
  title={Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.},
  author={H Chin and Ayako Arai and Hiroshi Wakao and Ryuichi Kamiyama and Nobuyuki Miyasaka and Osamu Miura},
  journal={Blood},
  year={1998},
  volume={91 10},
  pages={3734-45}
}
Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo receptor (EpoR) lacks the tyrosine kinase domain. We have previously shown that the Jak2 tyrosine kinase couples with the EpoR to transduce a growth signal. In the present study, we demonstrate that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E. Coexpression experiments in COS7… CONTINUE READING