Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.

@article{Charles2009LynKC,
  title={Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.},
  author={Nicolas Charles and Wendy T Watford and Hayde{\'e} L. Ramos and Lars Hellman and Hans C. Oettgen and Gregorio Rodr{\'i}guez G{\'o}mez and John Jack Ryan and John J O'Shea and Juan A Rivera},
  journal={Immunity},
  year={2009},
  volume={30 4},
  pages={533-43}
}
T helper 1 (Th1)-Th2 cell balance is key to host defense and its dysregulation has pathophysiological consequences. Basophils are important in Th2 cell differentiation. However, the factors controlling the onset and extent of basophil-mediated Th2 cell differentiation are unknown. Here, we demonstrate that Lyn kinase dampened basophil expression of the transcription factor GATA-3 and the initiation and extent of Th2 cell differentiation. Lyn-deficient mice had a marked basophilia, a… CONTINUE READING

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