Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

@article{OLaughlinBunner2001LynIR,
  title={Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.},
  author={B O'Laughlin-Bunner and Nina Radosevic and Marcia L Taylor and Shivakrupa and C S Deberry and Dean D Metcalfe and Mi Zhou and Clifford Lowell and Diana Linnekin},
  journal={Blood},
  year={2001},
  volume={98 2},
  pages={343-50}
}
Stem cell factor (SCF) binds to c-Kit and is an important mediator of survival, growth, and function of hematopoietic progenitor cells and mast cells. Lyn and other Src family members are activated by SCF and associate with phosphorylated tyrosine residues in the c-Kit juxtamembrane region. However, studies using c-Kit mutants incapable of directly recruiting Src family members suggest this kinase family plays a minimal role in c-Kit stimulus-response coupling mechanisms. The objective of this… CONTINUE READING

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