Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

  title={Lyn is a redox sensor that mediates leukocyte wound attraction in vivo},
  author={Sa Kan Yoo and Taylor W. Starnes and Qing Deng and Anna Huttenlocher},
Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type of ‘unhealed wound’—generate hydrogen peroxide (H2O2) through an NADPH oxidase (NOX). This extracellular H2O2 mediates recruitment of leukocytes, particularly the first responders of innate immunity, neutrophils, to injured tissue. However, the sensor that neutrophils use to detect the redox state at wounds is unknown. Here we identify the Src family kinase (SFK) Lyn as a redox sensor that mediates initial… CONTINUE READING
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