Lymphotoxin regulates commensal responses to enable diet-induced obesity

@article{Upadhyay2012LymphotoxinRC,
  title={Lymphotoxin regulates commensal responses to enable diet-induced obesity},
  author={Vaibhav Upadhyay and Valeriy A. Poroyko and Tae Jin Kim and Suzanne Devkota and Sherry Fu and Donald J. Liu and Alexei V Tumanov and Ekaterina P. Koroleva and Liufu Deng and Cathryn Nagler and Eugene B Chang and Hong Tang and Yang-Xin Fu},
  journal={Nature Immunology},
  year={2012},
  volume={13},
  pages={947-953}
}
Microbiota are essential for weight gain in mouse models of diet-induced obesity (DIO), but the pathways that cause the microbiota to induce weight gain are unknown. We report that mice deficient in lymphotoxin, a key molecule in gut immunity, were resistant to DIO. Ltbr−/− mice had different microbial community composition compared to their heterozygous littermates, including an overgrowth of segmented filamentous bacteria (SFB). Furthermore, cecal transplantation conferred leanness to germ… CONTINUE READING
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