Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen.

@article{Chin2006LymphotoxinPA,
  title={Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen.},
  author={Robert K. Chin and Mingzhao Zhu and Peter A Christiansen and Wenhua Liu and Carl F Ware and Leena Peltonen and Xuejun Zhang and Linjie Guo and Shuhua Han and Biao Zheng and Yang-Xin Fu},
  journal={Journal of immunology},
  year={2006},
  volume={177 1},
  pages={290-7}
}
Ectopic expression of peripherally restricted Ags by medullary thymic epithelial cells (mTECs) is associated with negative selection. Autoimmune regulator (AIRE) is considered to be the master regulator of these Ags. We show in this study that the ectopic expression of type II collagen (CII) in mTECs and the corresponding central tolerance to CII are AIRE independent but lymphotoxin dependent. The failure to properly express CII in mTECs of Lta(-/-) and Ltbr(-/-) mice leads to overt… CONTINUE READING