Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus.

@article{Schneider2008LymphotoxinmediatedCB,
  title={Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus.},
  author={Kirsten Schneider and Andrea Loewendorf and Carl de Trez and James Fulton and Antje Rhode and Heather M Shumway and Sukwon Ha and Ginelle Patterson and Klaus Pfeffer and Sergei A. Nedospasov and Carl F Ware and Chris A Benedict},
  journal={Cell host & microbe},
  year={2008},
  volume={3 2},
  pages={67-76}
}
Toll-like receptor (TLR)-dependent pathways control the production of IFNalphabeta, a key cytokine in innate immune control of viruses including mouse cytomegalovirus (MCMV). The lymphotoxin (LT) alphabeta-LTbeta receptor signaling pathway is also critical for defense against MCMV and thought to aid in the IFNbeta response. We find that upon MCMV infection, mice deficient for lymphotoxin (LT)alphabeta signaling cannot mount the initial part of a biphasic IFNalphabeta response, but show normal… CONTINUE READING

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