Lymphotoxin cytotoxicity, a combination of cytolytic and cytostatic cellular responses.

@article{Evans1981LymphotoxinCA,
  title={Lymphotoxin cytotoxicity, a combination of cytolytic and cytostatic cellular responses.},
  author={Christopher H. Evans and J A Heinbaugh},
  journal={Immunopharmacology},
  year={1981},
  volume={3 4},
  pages={347-59}
}
Guinea pig lymphotoxin inhibits the growth of mouse alpha L929 and guinea pig 104C1 tumor cells with lethal doses (LD 50's) of 0.4 and 200 units lymphotoxin/ml, respectively, in a colony inhibition assay. Refeeding with lymphotoxin-free medium is followed by resumption of 104C1 but not alpha L929 cell growth. This suggests that growth inhibition of alpha L929 is primarily due to cytolytic mechanisms, while that of 104C1 cells is due to cytostatic mechanisms. This is confirmed by radionuclide… CONTINUE READING

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