Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid.

@article{Furtado2007LymphotoxinBR,
  title={Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid.},
  author={Glaucia C Furtado and Tatjana Marinkovic and Andrea P Martin and Alexandre Garin and Benjamin Hoch and Wolfgang Hubner and Benjamin K. Chen and Eric M. Genden and Mihaela Skobe and Sergio A Lira},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 12},
  pages={5026-31}
}
Infiltration of lymphocytes into the thyroid gland and formation of lymph node-like structures is a hallmark of Hashimoto's thyroiditis. Here we demonstrate that lymphatic vessels are present within these infiltrates. Mice overexpressing the chemokine CCL21 in the thyroid (TGCCL21 mice) developed similar lymphoid infiltrates and lymphatic vessels. TGCCL21 mice lacking mature T and B cells (RAGTGCCL21 mice) did not have cellular infiltrates or increased number of lymphatic vessels compared with… CONTINUE READING
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