Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.

@article{Lkhagvasuren2013LymphotoxinR,
  title={Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.},
  author={Enkhsaikhan Lkhagvasuren and Mie Sakata and Izumi Ohigashi and Yousuke Takahama},
  journal={Journal of immunology},
  year={2013},
  volume={190 10},
  pages={5110-7}
}
Medullary thymic epithelial cells (mTECs) play a pivotal role in the establishment of self-tolerance in T cells by ectopically expressing various tissue-restricted self-Ags and by chemoattracting developing thymocytes. The nuclear protein Aire expressed by mTECs contributes to the promiscuous expression of self-Ags, whereas CCR7-ligand (CCR7L) chemokines expressed by mTECs are responsible for the attraction of positively selected thymocytes. It is known that lymphotoxin signals from the… CONTINUE READING
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