Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil.

@article{Pedrazzoli1987LymphoproliferativeDO,
  title={Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil.},
  author={Paolo Pedrazzoli and Mario Cazzola and Carmelo Carlo Stella and Giovanbattista Ippoliti and Federica Meloni},
  journal={Tumori},
  year={1987},
  volume={73 2},
  pages={117-9}
}
A 54-year-old woman presented with hepatosplenomegaly, anemia, neutropenia and lymphocytosis. Most peripheral blood lymphocytes had the surface antigens T3+, Leu11+ and were morphologically large granular lymphocytes. Bone marrow presented 60% lymphoid infiltration. Treatment with chlorambucil produced complete reversal of hepatosplenomegaly, anemia, neutropenia and lymphocytosis, and reduction of marrow infiltration. The patient is well 12 months after discontinuation of therapy. 
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