Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.

@article{Knies2015LymphomagenicCS,
  title={Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.},
  author={Nathalie Knies and Beg{\"u}m Alankus and Andr{\'e} Weilemann and Alexandar Tzankov and Kristina Brunner and Tanja Ruff and Markus Kremer and Ulrich Keller and Georg Lenz and Juergen Ruland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 52},
  pages={E7230-8}
}
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-κB) activation, which is required for tumor cell survival. BCR-induced NF-κB activation requires caspase recruitment domain-containing protein 11 (CARD11), and CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymphoma (DLBCL). To investigate the consequences of dysregulated… CONTINUE READING
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regulates immune activation

  • A Gewies
  • 2014

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