Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure.

@article{Castro2008LymphomaAL,
  title={Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure.},
  author={David J Castro and Christiane V L{\"o}hr and Kay A. Fischer and Clifford B Pereira and David Edward Williams},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={233 3},
  pages={454-8}
}
The fetus and neonate cannot be viewed as "little adults"; they are highly sensitive to toxicity from environmental chemicals. This phenomenon contributes to the fetal basis of adult disease. One example is transplacental carcinogenesis. Animal models demonstrate that environmental chemicals, to which pregnant women are daily exposed, can increase susceptibility of the offspring to cancer. It is uncertain to what degree in utero vs. lactational exposure contributes to cancer, especially for… CONTINUE READING
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