Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.

@article{Oppenheim1982LymphokinesTR,
  title={Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.},
  author={Joost J Oppenheim and Beda M. Stadler and Reuben P. Siraganian and Marilyne Mage and Bonnie J. Mathieson},
  journal={Federation proceedings},
  year={1982},
  volume={41 2},
  pages={257-62}
}
Interleukin 1, or IL 1, otherwise known as lymphocyte-activating factor, is a macrophage-derived 12,000- to 15,000-dalton polypeptide. Isoelectric focusing of human IL 1 reveals three peaks at pI's of 5.2, 6.0 and 6.9 respectively. IL 1 can be depleted of lymphocyte-derived IL 2 by SP-Sephadex chromatography. IL 1 augments the mitogenic response of PNA- Lyt 1+ thymocytes, and promotes thymocyte helper functions and B cell antibody production. IL 1 induces stable E rosette formation and the… CONTINUE READING
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