Lymphokines, including interleukin-2, alter gonadotropin-stimulated progesterone production and proliferation of human granulosa-luteal cells in vitro.

@article{Wang1991LymphokinesII,
  title={Lymphokines, including interleukin-2, alter gonadotropin-stimulated progesterone production and proliferation of human granulosa-luteal cells in vitro.},
  author={L J Wang and Sarah A. Robertson and Robert F. Seamark and Robert J. Norman},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={72 4},
  pages={
          824-31
        }
}
The effects of human interleukin-1 (IL-1) and IL-2 on human granulosa-luteal cell progesterone production were examined with or without hCG stimulation in vitro. Human granulosa-luteal cells were recovered from follicular fluid obtained from women undergoing in vitro fertilization procedures and cultured for up to 7 days before supernatant progesterone level measurement. Lymphokine-rich conditioned medium was prepared from mitogen-stimulated human peripheral blood leukocytes (HPL-CM). The… 
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It is demonstrated that IL-1 beta induces ovulation in the rat ovary, and this effect may be partly mediated by the increased production of the ovulatory mediator progesterone.
Effects of cytokines on prostaglandin production and steroidogenesis of incubated preovulatory follicles of the rat.
TLDR
The effects of three different lymphocyte- and macrophage-derived cytokines on the production of ovulatory mediators such as prostaglandins and progesterone in the preovulatory follicle of the eCG/hCG-primed immature rat are examined.
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