Lymphokines, including interleukin-2, alter gonadotropin-stimulated progesterone production and proliferation of human granulosa-luteal cells in vitro.
@article{Wang1991LymphokinesII, title={Lymphokines, including interleukin-2, alter gonadotropin-stimulated progesterone production and proliferation of human granulosa-luteal cells in vitro.}, author={L J Wang and Sarah A. Robertson and Robert F. Seamark and Robert J. Norman}, journal={The Journal of clinical endocrinology and metabolism}, year={1991}, volume={72 4}, pages={ 824-31 } }
The effects of human interleukin-1 (IL-1) and IL-2 on human granulosa-luteal cell progesterone production were examined with or without hCG stimulation in vitro. Human granulosa-luteal cells were recovered from follicular fluid obtained from women undergoing in vitro fertilization procedures and cultured for up to 7 days before supernatant progesterone level measurement. Lymphokine-rich conditioned medium was prepared from mitogen-stimulated human peripheral blood leukocytes (HPL-CM). The…
49 Citations
Interleukin-1: local production and modulation of human granulosa luteal cells steroidogenesis.
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Cellular composition of primary cultures of human granulosa-lutein cells and the effect of cytokines on cell proliferation.
- Biology, MedicineReproduction, fertility, and development
- 1995
Any observed effects from the addition of cytokines in this system may be due to indirect effects of cytokine-activated leukocytes on granulosa-lutein cells.
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- Biology, MedicineMolecular human reproduction
- 1996
Results show that GM-CSF is expressed and secreted by cells within the human ovary, and, together with the finding of expression of mRNA for GM- CSF receptor, suggest a role for GM -CSF in the local regulation of ovarian events.
Interleukin-1beta inhibits steroidogenic bioactivity in cultured rat ovarian granulosa cells by stimulation of progesterone degradation and inhibition of estrogen formation.
- Biology, MedicineBiology of reproduction
- 1998
An IL-1beta-mediated inhibition of gonadotropin-stimulated steroidogenesis via modulation of specific enzymes is demonstrated, and a role for IL- 1beta is suggested in mediating the observed decline of these bioactive hormones during ovulation and luteolysis.
Tumor necrosis factor alpha in the human ovary: presence in follicular fluid and effects on cell proliferation and prostaglandin production.
- Biology, MedicineFertility and sterility
- 1992
Evidence that granulosa cells inhibit interleukin-1α and interleukin-2 production from follicular lymphomonocytes
- Biology, MedicineJournal of Assisted Reproduction and Genetics
- 2005
These results suggest that preovulation, a migration of lymphomonocytes from the peripheral compartment to the follicle occurs, and unfavorable effects of IL2 and IL1α, cytotoxic and antisteroidogenetic activities, are counteracted by the products of granulosa cells.
Ovulatory effect of interleukin-1 beta on the perfused rat ovary.
- Biology, MedicineEndocrinology
- 1993
It is demonstrated that IL-1 beta induces ovulation in the rat ovary, and this effect may be partly mediated by the increased production of the ovulatory mediator progesterone.
Interleukin-1β inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric oxide and prostaglandin E accumulation
- Biology, MedicineMolecular and Cellular Endocrinology
- 1997
Effects of cytokines on prostaglandin production and steroidogenesis of incubated preovulatory follicles of the rat.
- Biology, MedicineBiology of reproduction
- 1993
The effects of three different lymphocyte- and macrophage-derived cytokines on the production of ovulatory mediators such as prostaglandins and progesterone in the preovulatory follicle of the eCG/hCG-primed immature rat are examined.
Cytokine-mediated regulation of rat ovarian function: interleukin-1 inhibits plasminogen activator activity through the induction of plasminogen activator inhibitor-1 (PAI-1)
- BiologyMolecular and Cellular Endocrinology
- 1994
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