Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.

@article{Kung1998LymphokineRO,
  title={Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.},
  author={Janice Kung and Denis Eugene Beller and S-T. Ju},
  journal={Cellular immunology},
  year={1998},
  volume={185 2},
  pages={
          158-63
        }
}
Recent studies using IL-2R alpha knockout mice have generated conflicting results regarding the hypothesis that IL-2/IL-2R interaction is obligatory for the development of AICD, which plays a central and pivotal role in maintaining peripheral tolerance. A relevant consequence of AICD defect is the demonstrated development of autoimmune lymphoproliferative disease in IL-2, IL-2R alpha, and IL-2R beta knockout mice, but not in IL-4, IL-7, or IL-7R knockout mice. Whether IL-4, IL-7, or IL-15 can… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Via an IL-2-Dependent Mechanism IL-4 Potentiates Activated T Cell Apoptosis

Katalin Mikecz, Tibor T. Glant, +4 authors Jurg Tschopp
  • 2003
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers

Loading similar papers…