Lymphokine enhances oxygen-independent activity against intracellular pathogens

  title={Lymphokine enhances oxygen-independent activity against intracellular pathogens},
  author={Henry W. Murray and Gerald I. Byrne and Constance D Rothermel and D M Cartelli},
  journal={The Journal of Experimental Medicine},
  pages={234 - 239}
To determine if mechanisms other than the generation of toxic oxygen intermediates are active against intracellular pathogens, oxidatively deficient mouse L cells and monocyte-derived macrophages from patients with chronic granulomatous disease were stimulated with soluble lymphocyte products. Despite no enhancement in oxidative activity, these cells displayed effective microbistatic activity against both T. gondii and C. psittaci. These results suggest a potential role for nonoxidative… CONTINUE READING

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Growth ofChIamydia psittaci in human monocytes

  • C. D. Rothermel, G. I. Byrne, H. W. Murray
  • 22nd Interscience Conference on Antimicrobial…
  • 1982

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