Lymphokine-activated killer cell cytotoxicity against human colon carcinomas enhanced by monoclonal antibody D612.

@article{Pendurthi1990LymphokineactivatedKC,
  title={Lymphokine-activated killer cell cytotoxicity against human colon carcinomas enhanced by monoclonal antibody D612.},
  author={Tribhuvan K. Pendurthi and Reno Parker and Jeffrey Schlom and F. James Primus},
  journal={International journal of cancer},
  year={1990},
  volume={46 6},
  pages={1021-8}
}
The antibody-dependent cellular cytotoxicity (ADCC) properties of a murine monoclonal antibody (MAb), designated D612 (IgG2a), which reacts with human colon carcinomas, was studied using normal human peripheral blood lymphocytes (PBMNC). Although the level of ADCC of PBMNC with D612 varied among different donors, it was 20 to 30 times higher than the lytic activity of control cultures containing isotype-matched control MAb. Incubation of PBMNC with recombinant interleukin-2 (IL-2) resulted in a… CONTINUE READING

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