Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

@article{Stanford2010LymphoidTP,
  title={Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases},
  author={Stephanie M. Stanford and Tomas M. Mustelin and Nunzio Bottini},
  journal={Seminars in Immunopathology},
  year={2010},
  volume={32},
  pages={127-136}
}
A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR… CONTINUE READING
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