Lymphoid tissue targeting of anti-HIV drugs using liposomes.

@article{Desormeaux2005LymphoidTT,
  title={Lymphoid tissue targeting of anti-HIV drugs using liposomes.},
  author={Andre Baguenier Desormeaux and Michel G. Bergeron},
  journal={Methods in enzymology},
  year={2005},
  volume={391},
  pages={330-51}
}
Considering that HIV-1 accumulates and replicates actively within lymphoid tissues, any strategy that will decrease viral stores in these tissues might be beneficial to the infected host. Follicular dendritic cells (FDC), B lymphocytes, antigen-presenting cells like macrophages, and activated CD4(+) T cells are abundant in lymphoid tissues, and all express substantial levels of the HLA-DR determinant of the major histocompatibility complex class II (MHC-II). Monocyte-derived macrophages, which… CONTINUE READING
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