Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes.

  title={Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes.},
  author={Wenxian Zeng and Claudia Baumann and Anja Schmidtmann and Ali Honaramooz and Lin Tang and Alla Bondareva and Camila Dores and Tao Fan and Sichuan Xi and Theresa M. Geiman and Rahul Rathi and Dirk G de Rooij and Rabindranath De La Fuente and Kathrin Muegge and Ina Dobrinski},
  journal={Biology of reproduction},
  volume={84 6},
Lymphoid-specific helicase (HELLS; also known as LSH) is a member of the SNF2 family of chromatin remodeling proteins. Because Hells-null mice die at birth, a phenotype in male meiosis cannot be studied in these animals. Allografting of testis tissue from Hells(-/-) to wild-type mice was employed to study postnatal germ cell differentiation. Testes harvested at Day 18.5 of gestation from Hells(-/-), Hells(+/-), and Hells(+/+) mice were grafted ectopically to immunodeficient mice… CONTINUE READING