Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells

@article{Pault1991LymphoidRO,
  title={Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells},
  author={Bruno P{\'e}ault and Irving L Weissman and Charles M. Baum and Joseph M McCune and Ann S Tsukamoto},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={1283 - 1286}
}
The search for human hematopoietic stem cells has been hampered by the lack of appropriate assay systems. Demonstration of the ability of precursor cell candidates to give rise to T cells is of significant difficulty since dissociated in vitro cultured thymus stroma cells lose their ability to sustain thymocyte maturation. To define further the differentiative capacities of the rare human fetal liver and bone marrow cells that express the CD34 surface antigen and exhibit in vitro myeloid and… CONTINUE READING