Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status.

@article{Kobayashi2002LymphoidFA,
  title={Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status.},
  author={Akiko Kobayashi and Teresa Marie Darragh and Brian G. Herndier and Kathryn M Anastos and Howard Minkoff and Mardge Cohen and Mary Young and Alexandra M. Levine and Linda Ahdieh Grant and William Hyun and Vivian A. Weinberg and Ruth M. Greenblatt and Karen K. Smith-McCune},
  journal={The American journal of pathology},
  year={2002},
  volume={160 1},
  pages={151-64}
}
The exact role of the mucosal immune response in the pathogenesis of human papillomavirus (HPV)-related premalignant and malignant diseases of the genital tract is poorly understood. We used immunohistochemical analysis to characterize immune cells in normal cervix (N = 21), HIV-negative high-grade dysplasia (N = 21), and HIV-positive high-grade dysplasia (N = 30). Classical germinal centers were present in 4.7% of normal cervix, 33% of high-grade lesions from HIV-negative women, and 3.3% of… CONTINUE READING

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