Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

  title={Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration},
  author={Mathias Heikenwalder and Magdalini Polymenidou and Tobias Junt and Christina J Sigurdson and Hermann Wagner and Shizuo Akira and Rolf Martin Zinkernagel and Adriano Aguzzi},
  journal={Nature Medicine},
DNA containing unmethylated cytidyl guanosyl (CpG) sequences, which are underrepresented in mammalian genomes but prevalent in prokaryotes, is endocytosed by cells of the innate immune system, including macrophages, monocytes and dendritic cells, and activates a pathway involving Toll-like receptor-9 (TLR9). CpG-containing oligodeoxynucleotides (CpG-ODN) are potent stimulators of innate immunity, and are currently being tested as adjuvants of antimicrobial, antiallergic, anticancer and… CONTINUE READING


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