Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome

  title={Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome},
  author={Anthony Wing-Hung Chan and Joanna Hung-Man Tong and Yi-lian Pan and Stephen Lam Chan and Grace Lai‐Hung Wong and Vincent Wai‐Sun Wong and Paul B. S. Lai and Ka Fai To},
  journal={The American Journal of Surgical Pathology},
  • A. Chan, J. Tong, K. To
  • Published 28 February 2015
  • Medicine, Biology
  • The American Journal of Surgical Pathology
Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is an uncommon variant of HCC with only 22 cases reported in the literature. To better determine the incidence, clinicopathologic features, prognostic significance, and molecular pathogenesis of LEL-HCC, we presented the largest series of LEL-HCC from a 9-year retrospective cohort of patients with HCC undergoing surgical resection. LEL-HCC was identified in 20 patients (4.9%). Compared with patients having HCC without significant tumor… 
Lymphoepithelioma-like hepatocellular carcinoma
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Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature.
The clinicopathological features of the case are reported, along with a review of the few cases present in the literature, to report on the synchronous occurrence of HCC and GIST.
Synchronous hepatocellular carcinoma and lymphoepithelioma-like carcinoma arising from 2 different sites of the liver
This is an interesting case providing circumstantial evidence of simultaneous development of HCC and LEL-HCC in distinct nodules of the liver with a background of chronic hepatitis B virus infection.
Lymphoepithelioma-like Hepatocellular Carcinoma: a Case Report and Review of Literature
A case of hepatic lymphoepithelioma-like carcinoma-hepatocellular carcinoma subtype (LEL-HCC), a rare variant of HCC with a relatively better prognosis, in a 41-year-old man with chronic hepatitis C virus infection is reported.
 Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of PD-L1 expression.
A 73-year-old female with chronic hepatitis B who developed metastatic lesions 5 years after underwent resection for LEL-HCC showed a spectrum of morphologic findings, which could be mistaken for other entities such as lymphoma, particularly in lesions with single-cell infiltrate pattern and abundant tumor-infiltrating lymphocytes.
Lymphoepithelioma-Like Cholangiocarcinoma Associated With HCV: A Case Report and a Review of the Literature
A rare cases of HCV-associated LEL-CC that coexisted with other malignancy and that was associated with survival for more than 3 years after surgery is described, suggesting that surgical resection may be the recommended therapeutic option for Lel-CC.
Lymphoepithelioma-Like Hepatocellular Carcinoma: Report of Three Cases and Review of Literature
Three cases of lymphoepithelioma-like hepatocellular carcinoma (HCC) in one female and two male patients are reported, composed of a population of malignant cells with focal to diffuse positivity for HepPar-1, as well as a prominent lymphoplasmacytic infiltrate intimately associated with themalignant cells.
Lymphoepithelioma-like hepatocellular carcinoma: a case report with emphasis on the cytological features.
The cytological features of the present case represent both lymphoepithelioma-like carcinoma and conventional HCC, and the prognosis of LEL-HCC may be favorable.
Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature
It is suggested that even the locally advanced patients of LELC with postoperative recurrence and preoperative lymph node metastasis should be actively treated and intervened for a longer survival period.
Lymphoepithelioma-Like Carcinoma in Liver.


Lymphoepithelioma-like hepatocellular carcinoma.
This is the first confirmed case of HCC with an LELC component and it is reported that the patient was a 56-year-old man with chronic hepatitis C virus infection and cirrhosis, and EBER in situ hybridization was negative.
Lymphoepitelioma-like hepatocellular carcinoma: a case report and a review of the literature.
The association between the lack of EBV infection, the absence of cirrhosis, a "cytotoxic profile" of the inflammatory infiltrate and a good prognosis could identify a variant of lymphoepithelioma-like HCC with a favorable clinical outcome.
Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature
The clinicopathological features of this rare case of lymphoepithelioma-like hepatocellular carcinoma, reported in a 79-year-old Japanese man, are described for further understanding of the disease and review past cases in the literature.
Hepatocellular Lymphoepithelioma-Like Carcinoma Associated with Epstein Barr Virus: A Hitherto Unrecognized Entity
This case represents the first report of EBV-positive hepatocellular LELC arising in a cirrhotic liver with EBV demonstrated in the tumor cells and is particularly interesting given the precipitous clinical outcome, which was possibly related to immunosuppresive therapy.
Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration
Better prognosis of the LHCC group could attribute to the anti‐tumor effect induced by cellular immunity of CD8+ and CD4+ T lymphocytes, and partly by humoral immunity of B cells which formed lymph follicles.
Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases.
A better selection of exactly those patients presenting with an HCA with an amplified risk of malignant degeneration is advocated in order to reduce the number of liver resections and thus reducing the operative risk for these predominantly young patients.
Host inflammatory response predicts survival of patients with Epstein-Barr virus-associated gastric carcinoma.
The definition of LELC should be expanded to include EBV-associated GCs with CLR because these have a prognosis similar to L ELC and are likely to have a better survival rate than other GCs.
Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context
The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation.
A long-term surviving patient with hepatocellular carcinoma including lymphocytes infiltration--a clinicopathological study.
The patient in this case had hepatocellular carcinoma with a diffuse lymphocytes infiltration into the tumor and was able to survive for 6 yrs and 11 months without any cancer recurrence, and the inflammatory infiltrate may be related to a distinct category of patients with a favorable prognosis.