Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome

@article{Chan2015LymphoepitheliomalikeHC,
  title={Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome},
  author={Anthony Wing-Hung Chan and Joanna Hung-Man Tong and Yi-lian Pan and Stephen Lam Chan and Grace Lai‐Hung Wong and Vincent Wai‐Sun Wong and Paul B. S. Lai and Ka Fai To},
  journal={The American Journal of Surgical Pathology},
  year={2015},
  volume={39},
  pages={304–312}
}
  • A. Chan, J. Tong, K. To
  • Published 28 February 2015
  • Medicine, Biology
  • The American Journal of Surgical Pathology
Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is an uncommon variant of HCC with only 22 cases reported in the literature. To better determine the incidence, clinicopathologic features, prognostic significance, and molecular pathogenesis of LEL-HCC, we presented the largest series of LEL-HCC from a 9-year retrospective cohort of patients with HCC undergoing surgical resection. LEL-HCC was identified in 20 patients (4.9%). Compared with patients having HCC without significant tumor… 
Lymphoepithelioma-like hepatocellular carcinoma
TLDR
This case was the youngest patient of all the reported cases, and the third case who was infected with both hepatitis B virus (HBV) and hepatitis C virus (HCV).
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature.
TLDR
The clinicopathological features of the case are reported, along with a review of the few cases present in the literature, to report on the synchronous occurrence of HCC and GIST.
Synchronous hepatocellular carcinoma and lymphoepithelioma-like carcinoma arising from 2 different sites of the liver
TLDR
This is an interesting case providing circumstantial evidence of simultaneous development of HCC and LEL-HCC in distinct nodules of the liver with a background of chronic hepatitis B virus infection.
Lymphoepithelioma-like Hepatocellular Carcinoma: a Case Report and Review of Literature
TLDR
A case of hepatic lymphoepithelioma-like carcinoma-hepatocellular carcinoma subtype (LEL-HCC), a rare variant of HCC with a relatively better prognosis, in a 41-year-old man with chronic hepatitis C virus infection is reported.
 Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of PD-L1 expression.
TLDR
A 73-year-old female with chronic hepatitis B who developed metastatic lesions 5 years after underwent resection for LEL-HCC showed a spectrum of morphologic findings, which could be mistaken for other entities such as lymphoma, particularly in lesions with single-cell infiltrate pattern and abundant tumor-infiltrating lymphocytes.
Lymphoepithelioma-Like Cholangiocarcinoma Associated With HCV: A Case Report and a Review of the Literature
TLDR
A rare cases of HCV-associated LEL-CC that coexisted with other malignancy and that was associated with survival for more than 3 years after surgery is described, suggesting that surgical resection may be the recommended therapeutic option for Lel-CC.
Lymphoepithelioma-Like Hepatocellular Carcinoma: Report of Three Cases and Review of Literature
TLDR
Three cases of lymphoepithelioma-like hepatocellular carcinoma (HCC) in one female and two male patients are reported, composed of a population of malignant cells with focal to diffuse positivity for HepPar-1, as well as a prominent lymphoplasmacytic infiltrate intimately associated with themalignant cells.
Lymphoepithelioma-like hepatocellular carcinoma: a case report with emphasis on the cytological features.
TLDR
The cytological features of the present case represent both lymphoepithelioma-like carcinoma and conventional HCC, and the prognosis of LEL-HCC may be favorable.
Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature
TLDR
It is suggested that even the locally advanced patients of LELC with postoperative recurrence and preoperative lymph node metastasis should be actively treated and intervened for a longer survival period.
Lymphoepithelioma-Like Carcinoma in Liver.
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