Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone.

@article{Miller2007LymphodepletionFB,
  title={Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone.},
  author={Jeffrey S Miller and Daniel J. Weisdorf and Linda Jean Burns and Arne Slungaard and John E Wagner and Michael R. Verneris and Sarah Cooley and Rosanna Wangen and Susan K Fautsch and Roby Nicklow and Todd E Defor and Bruce R Blazar},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={
          2761-3
        }
}
Donor lymphocyte infusions (DLIs) can produce lasting remissions in patients with relapsed chronic myeloid leukemia (CML), but are less effective in non-CML diseases. We hypothesized that lymphodepletion, achieved with cyclophosphamide (Cy) and fludarabine (Flu), would promote in vivo expansion of the infused lymphocytes enhancing their immunologic effects. Fifteen patients with relapsed non-CML disease who received Cy/Flu/DLI were compared with 63 controls who received DLI without chemotherapy… CONTINUE READING
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