• Biology, Medicine
  • Published in
    The American journal of…
    1993

Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA).

@article{Gelb1993LymphocytesIP,
  title={Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA).},
  author={Arnold B Gelb and Bruce Robert Smoller and Roger A. Warnke and Louis J Picker},
  journal={The American journal of pathology},
  year={1993},
  volume={142 5},
  pages={
          1556-64
        }
}
The cutaneous lymphocyte-associated antigen (CLA) is the T-cell ligand for E-selectin and is involved in tissue selective migration of memory/effector T cells to chronic inflammatory sites in skin. Here, we examine the hypothesis that CLA is also involved in the local host immune response to cutaneous neoplasms. Eleven primary cutaneous melanomas, nine primary cutaneous squamous cell carcinomas, and 11 assorted neoplasms metastatic to cutaneous and noncutaneous sites were immunostained with… CONTINUE READING

Citations

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Selectin glycoprotein ligands.