Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity

@article{Romanova2017LymphocytesII,
  title={Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity},
  author={Elena A. Romanova and Elena A. Dukhanina and Tatiana N Sharapova and Lidia P Sashchenko and Nikolai V. Gnuchev and D V Yashin},
  journal={Doklady Biological Sciences},
  year={2017},
  volume={472},
  pages={31-33}
}
Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7–Hsp70 complex, which is accompanied by a loss of both the Tag7–Mts1-mediated… CONTINUE READING