Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

@article{Modlin1989LymphocytesBA,
  title={Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions},
  author={Robert. L. Modlin and Claude Pirmez and Florence M. Hofman and Victoria Torigian and Koichi Uyemura and Thomas H. C. Rea and Barry R. Bloom and Michael B Brenner},
  journal={Nature},
  year={1989},
  volume={339},
  pages={544-548}
}
THE majority of T cells bear the T-cell receptor (TCR) αβ complex which recognizes foreign antigen peptides only in the context of self major histocompatibility complex (MHC) molecules1. Such T cells function in a variety of effector roles and secrete cytokines that mediate the activation and differentiation of other cells in the immune system. Recently, a small subpopulation T cells was found to bear a distinct TCR composed of γ and δ subunits2. In man, TCR γδ+ cells are distributed as ~5 per… CONTINUE READING
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