Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains

@article{Milln2006LymphocyteTM,
  title={Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains},
  author={Jaime Mill{\'a}n and Lindsay Hewlett and Matthew C. P. Glyn and Derek Toomre and Patricia Clark and Anne J Ridley},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={113-123}
}
During inflammation, leukocytes bind to the adhesion receptors ICAM-1 and VCAM-1 on the endothelial surface before undergoing transendothelial migration, also called diapedesis. ICAM-1 is also involved in transendothelial migration, independently of its role in adhesion, but the molecular basis of this function is poorly understood. Here we demonstrate that, following clustering, apical ICAM-1 translocated to caveolin-rich membrane domains close to the ends of actin stress fibres. In these F… CONTINUE READING
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