Lymphocyte subsets in granulomas of human tuberculosis: an in situ immunofluorescence study using monoclonal antibodies.

@article{Randhawa1990LymphocyteSI,
  title={Lymphocyte subsets in granulomas of human tuberculosis: an in situ immunofluorescence study using monoclonal antibodies.},
  author={Parmjeet Singh Randhawa},
  journal={Pathology},
  year={1990},
  volume={22 3},
  pages={153-5}
}
The immunophenotypic characteristics of lymphocyte subpopulations in tissue lesions of human tuberculosis were investigated in 18 cases. Frozen sections of affected cervical lymph nodes were stained with a panel of monoclonal antibodies using avidin-biotin immunofluorescence technique. The mean percentage of cells staining with different antibodies was as follows: CD3 44%; CD4 43%; CD8 36%; HLA-DR 86%; and IgM 29%. The mean CD4/CD8 ratio was 1.3:1. Leu7 and CD1 staining cells were very sparsely… CONTINUE READING

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