Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization.

@article{Loetscher1998LymphocytespecificCR,
  title={Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization.},
  author={Marcel Loetscher and Pius Loetscher and Nicole Brass and Eckart Meese and Bernhard Moser},
  journal={European journal of immunology},
  year={1998},
  volume={28 11},
  pages={3696-705}
}
Expression of CXCR3, the receptor for the CXC chemokines IFN-gamma-inducible 10-kDa protein (IP10) and monokine induced by IFN-gamma (Mig), in human T lymphocytes and their responses to IP10 and Mig were analyzed. About 40 % of resting T lymphocytes (and low numbers of B cells and natural killer cells) stained positive for CXCR3 but these cells did not express CXCR3 transcripts and did not respond to these chemokines. However, treatment with IL-2 with or without addition of phytohemagglutinin… CONTINUE READING