Lymphocyte responses in patients with total hip arthroplasty.

  title={Lymphocyte responses in patients with total hip arthroplasty.},
  author={Nadim James Hallab and Shelley Anderson and T. J. F. Stafford and Tibor Glant and Joshua.J. Jacobs},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={23 2},
How lymphocyte-mediated metal sensitivity affects orthopaedic implant performance remains poorly understood. Do patients with implants exhibit elevated lymphocyte reactivity to metals and is this reactivity more generalized or more implant-alloy specific? We investigated these questions by measuring lymphocyte responses to implant metals (Cr(+3), Co(+2), Ni(+2) at 0.1mM, and Ti(+4) at 0.001 mM) in six subject groups: Group 1a=young controls, Group 1b=age matched controls, Group 2a=subjects with… CONTINUE READING
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