Lymphocyte radiosensitivity correlated with pelvic radiotherapy morbidity.

  title={Lymphocyte radiosensitivity correlated with pelvic radiotherapy morbidity.},
  author={T K Lee and Ron R. Allison and Kevin F O'Brien and Roberta M. Johnke and Karen I Christie and James L Naves and Charles J. Kovacs and Hyder H Arastu and Ulf Lennart Karlsson},
  journal={International journal of radiation oncology, biology, physics},
  volume={57 1},
PURPOSE To test the hypothesis that, before treatment, prostate cancer patients who demonstrate a high yield of ex vivo radiation-induced micronucleus (MN) in G(0) lymphocytes represent a patient population with a greater-than-average risk of developing radiotherapy (RT)-related morbidity. METHODS AND MATERIALS We prospectively conducted the cytokinesis-block MN assay of peripheral blood lymphocytes (PBLs) in 38 prostate cancer patients. Before the initiation of RT, PBLs from each patient… CONTINUE READING