Lymphocyte/monocyte ratio in osteoarticular tuberculosis in children: a haematological biomarker revisited.


INTRODUCTION *Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy. MATERIAL AND METHODS Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed. RESULTS The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels. CONCLUSIONS The L/M ratio may have potential as an effective biomarker response.

DOI: 10.1177/0049475515609244

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@article{Agarwal2016LymphocytemonocyteRI, title={Lymphocyte/monocyte ratio in osteoarticular tuberculosis in children: a haematological biomarker revisited.}, author={Anil kumar Agarwal and Mohd Shafi Bhat and Anubrat Kumar and Abbas Shaharyar and Madhusudhan Mishra and Rajeev Ratan Singh Yadav}, journal={Tropical doctor}, year={2016}, volume={46 2}, pages={73-7} }