Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF.

Abstract

Lymphoid cell stimulation with phytohemagglutinin, converting quiescent lymphocytes into rapidly-proliferating lymphoblast-like cells, is tightly coordinated with the transcription of ribosomal genes. Nuclear Run-On assays demonstrated that after the addition of PHA ribosomal gene activity increased rapidly during the first 40 hrs. and within 64 hrs. it… (More)

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