Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus.

@article{Appel1982LymphocytemediatedIC,
  title={Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus.},
  author={Max J. G. Appel and William R. Shek and Brian Alan Summers},
  journal={Infection and immunity},
  year={1982},
  volume={37 2},
  pages={592-600}
}
Immune lymphocyte-mediated cytotoxicity (ILMC) was evaluated in dogs after intranasal exposure to one of the following three virulent strains of canine distemper virus: Cornell A75/17, Ohio R252, and Snyder Hill. Cytotoxicity was tested with peripheral blood lymphocytes as effector cells and primary dog testicle cells that were matched for histocompatibility as target cells. A strong correlation was found between ILMC and the course of the infection. Dogs that succumbed to encephalitis with any… CONTINUE READING