Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.

@article{Hata2006LymphocyteLO,
  title={Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.},
  author={Jonathan A. Hata and Matthew Leighton Williams and Jacob N. Schroder and Brian Lima and Janelle R. Keys and Burns C. Blaxall and Jason A. Petrofski and Andre M Jakoi and Carmelo A. Milano and Walter J Koch},
  journal={Journal of cardiac failure},
  year={2006},
  volume={12 5},
  pages={360-8}
}
BACKGROUND In human heart failure, increased expression of G protein-coupled receptor kinases (GRKs) causes the loss of beta-adrenergic receptor (betaAR) signaling and function. Mechanical unloading with a left ventricular assist device (LVAD) promotes reverse remodeling, which includes restoration of betaAR responsiveness. We tested the hypothesis that LVAD support of the failing human heart alters the expression and activity of GRKs and we sought to determine whether changes in myocardial… CONTINUE READING
32 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…